TEN TOP DIETARY SUPPLEMENTS
According to Vince
Updated February 2009
This is my FOURTH shot at ranking the topmost of the some 60+
supplements (some 135 pills) I take each day each day, according to how
important I feel they are for my health and longevity. I have also expanded the list of properties
of some of the substances. At this stage
of scientific knowledge, longevity for me involves:
Taking advantage of
recent biotech breakthroughs that produce understanding of cellular and
genetic effects known to prolong animal life and, at the same time, pending
more breakthroughs, warding off the main killer diseases that mow down most old
people in my age range: cancers, cardiovascular diseases, diabetes,
Parkinson’s, arthritis, Alzheimer’s, Gout, etc.
Studying and following the research literature on each
of the substances I take. There are new
important developments just about every week now. We are starting to learn how these substances
work through complex genetic pathways affecting the expression and functions of
hundreds of human genes.
Taking multiple supplements that reinforce each other
in their effects giving in-depth defense: anti-inflammatory, anti-oxidant,
killing cancer cells, supporting high mental functionality, avoiding collagen
cross-linking, clearing lipofuscin (a metabolic waste
product) out of cells.
So here is my list of the top ten supplements I take and why.
– a powerful antioxidant with known anti-cancer and cardiovascular
protective effects that acts through known genetic mechanisms to extend
the life of lower animals and life forms up to 35%. Protects normal cells from radiation and
other damage while causes cancer cells to destroy themselves.
Facilitates cellular repair. With
other beneficial effects such as protecting against some neurological
- Fish oils or other supplements
that contain a large amount of EPA and DHA. Very important for the control of
inflammation which is at the heart of many age-related diseases including
various forms of heart trouble. Potentially
useful for the prevention and treatment of type 2 diabetes mellitus. With
other beneficial effects such as warding off senile dementia, liver
protection, balancing diets with lots of meat and minimizing discogenic
- Curcumin, the active ingredient in
tumeric. Also a powerful
antioxidant, anti-inflammatory with powerful known anti-cancer
effects. Helps control cholesterol,
protects against Alzheimer’s disease and reverses cognitive function
damage of Alzheimer’s Disease, as well as other beneficial
- r-alpha lipoic acid
– another powerful antioxidant known to be capable of penetrating into
the mitochondria of cells (the energy-converting organs in cells) and
preventing oxidative damage to them.
Inhibits reproduction of the HIV virus. Reduces triglyceride and lipid
accumulation in tissues. Helps
control body weight. Prevents
diabetes mellitus in obese diabetes-prone rats.
- Actyl-l-carnitine –
a key substance related to cell metabolic processes that can also penetrate mitochondria and mitigate various
pathologies that can affect cell metabolism. A powerful antioxidant,
also helps clear lipofuscin and fight tissue glycation.
The combination of r-alpha lipoic acid and Actyl-l-carnitine is particularly powerful, impacting
the mitochondrial health of all cells in the
body. The combination can repair damaged
mitochondrial and restore functionality to what otherwise would be compromised
cells. Health implications include
eyesight and hearing improvement, enhanced vitality and sexual drive. Feeding these supplements to mice and lower
life forms extends lifespans 20% to 30%
compared to control groups. I suggest
taking 200mg of r-alpha lipoic acid and 500mg of Actyl-l-carnitine twice daily.
tea – lots of it, and/or green
tea extract. Active ingredient Epigallocatechin
Gallate reduces blood pressure, protects the heart against hypertension
damage, protects against cancers, hypercholesterolemia, atherosclerosis,
Parkinson's disease, Alzheimer's disease, and other aging-related disorders.
Has anti-inflammatory effects and contributes to limiting protein-sugar crosslinking (glycation). Important for weight control.
D-3 – 800 IU per day. There
have recently been major discoveries about the genetic actions of vitamin
D and what it does. Activating over
1,000 genes, it can help to prevent or mitigate autoimmune diseases,
infectious diseases and cancers. It
is a particularly important supplement to take during the winters when
there is insufficient UV light for the body to manufacture its own supply.
- L-Carnosine. I
take two 500mg caps twice a day.
This is a major pluripotent (having many effects) natural
substance. Besides being a powerful
anti-oxidant protecting against free-radical damage, inhibits the
formation of glycation (sugar-related protein cross linking) implicated in
diabetes, Alzheimer’s and other diseases, is neuroprotective, and appears
capable of delaying cell senescence in a number of cell types. Clears accumulated lipofuscin. I did a thorough literature review on
this substance a few years back and continue to be impressed by it.
Q10 (CoQ10): I take 100 or 150mg
twice daily. Q10 is both an
anti-inflammatory and a very powerful antioxidant that protects the
mitochondria and lipid membranes.
It helps assure the production of cellular energy.. Research studies have shown that it can
slow the progress of Parkinson’s Disease, protect against coronary artery
disease, and can help prevent hearing loss. Clinical trials evaluating CoQ10 have
been undertaken for several neurodegenerative diseases.
- Astragalus root – I take six standardized
capsules (0.5% astragolisides 250 mg per cap) per day. A traditional Chinese medicinal herb, astragalus has been the subject of extensive recent biomedical
research, clinical trials and pharmacological studies. A powerful immunostimulant,
it can restore the activity of a suppressed immune system. Useful for prevention of the common cold, as
an adjunct to cancer therapies, and for cardiovascular system improvement
related to angina, congestive heart failure and acute myocardial infarcts . Has
senility-preventing, antioxidizing and hepatoprotective properties
This is just the top ten of my
supplements, and there is much more to say about each one. And there are many other important ones. If you are interested in my complete longevity program including all the supplements I take, you can read my Anti-Aging Firewalls paper.
Research publications supporting the above comments can be
found by searching www.pubmed.org, a
database of the National Library of Medicine.
Google searches can produce additional research citations along with sometimes-questionable
claims of supplement-selling organizations.
Copyright 2008 by Vincent E. Giuliano. All rights reserved
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THIS INFORMATION IS NOT A SUBSTITUTE FOR A LICENSED PHYSICIAN’S MEDICAL ADVICE. IF ANY ADVICE, OPINIONS, OR INSTRUCTIONS HEREIN CONFLICT WITH THAT OF A TREATING LICENSED PHYSICIAN, DEFER TO THE OPINION OF THE PHYSICIAN. THIS INFORMATION IS INTENDED FOR PEOPLE IN GOOD HEALTH. IT IS THE USER’S RESPONSIBILITY TO KNOW HIS OR HER MEDICAL HISTORY AND ENSURE THAT SUPPLIMENTS HE OR SHE TAKES DO NOT CREATE AN ADVERSE REACTION.
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