–They are two sides of the same coin, representing differing viewpoints of molecular
biology and cell biology.
•Of course all the cells in an individual have the same genome but their DNA acquires additional epigenomic markers as they
differentiate. So, looked at in terms of DNA, the differences between kinds of cells including stem cells is one of epigenomics, e.g.
DNA methylation, histone acetylation,
binding-site molecular folding,
alterations in non-coding RNA, etc..
•Factors that can revert fully mature Type D cells to Type A pluripotent cells and possibly more differentiated stem
cell types are being actively
researched. Many new combinations of reprogramming factors have been discovered in addition
to the original ones: (Oct3/4, Sox2, Klf4, cMyc)
•