–Histone
acetylation (continued)
•
•Acetylation/deacetylation are known to be
involved in the activation or silencing
of multiple “aging,” “longevity” and stress-regulating genes including FOXO4, SIRT1.
•Longevity
proteins SIR2 and SIRT1 promote global deacetylation of histones. It
is thought that this deacetylase activity is responsible for silencing, recombination suppression and extension of life span in vivo in
lower organisms. FOXO4 is
deacetylated by SIRT1 promoting stress-regulating genes and cellular survival
•A main
mechanism used by curcumin, resveratrol and other dietary polyphenols for inhibition of gene activation by
NF-kappaB appears to be histone
deacetylation. Another is activation of
Nrf2.
•There can be
significant interplay between histone acetylation and DNA methylation,
particularly when gene silencing is involved.
–
•