•(Lunyak et al, others 2008 -
2012) have established that:
•Stem cell senescence results
from aging and demonstrably leads to diseases
and aging.
•Stem cell senescence is an
epigenetic phenomenon. In fact, SINE/Alu Retrotransposons are transcriptionally up-regulated upon
Senescence of hADSC,
and this affects chromatin structure and impairs the DNA damage repair machinery.
•Epigenetic interventions can
reverse cell senescence markers affecting
aging
•Small non-coding RNA species
(like IncRNAs, shRNAs, siRNAs and piALU
RNAs) can play critical roles in gene regulation, DNA repair and chromatin regulation
•In fact, SINE/Alu
Retrotransposons are transcriptionally up-regulated upon Senescence of hADSC, and this affects chromatin
structure and impairs the
DNA damage repair machinery.
•
•