•Lifelong accumulated damage in cellular DNA repair
machinery in adult stem cells appears to be a major
cause of stem cell senescence
»“Cellular aging is linked to deficiencies in efficient repair
of DNA double strand breaks and authentic genome maintenance at the chromatin
level. Aging poses a significant threat to adult stem cell function
by triggering persistent DNA damage and ultimately cellular senescence.”
»Further, “65% of naturally occurring repairable DNA damage in
self-renewing adult stem cells occurs within transposable elements”
of Alu RNA/DNA.
•