•The feedback loops between
many body systems are so tightly interrelated
that it is difficult to say where one theory leaves off and another one starts.
Examples:
–Neurological degeneration could be triggered by oxidative damage, lipofuscin accumulation,
inflammation, faulty mitochondrial signaling or defects in energy production.
–Chronic Inflammation is a part of an aging-related program that can be triggered by numerous stimuli, is generally mediated by
a gene activation sequence
triggered by overexpression of NF-kappaB and related factors, and is an entry portal to several other of the aging
related conditions including Tissue Glycation, Susceptibility to
Cardiovascular Disease, Neurological Degeneration, and Susceptibility
to Cancers.
–Telomere Shortening and Damage is one
possible cause of cell senescence,
apoptosis and mutations which in turn generate a number of the epigenomic-mediated aging conditions including Immune System Deterioriation, Susceptibility To
Cancers, Susceptibility to Cardiovascular Disease, Neurological Degeneration, and atrophy of hormone-producing organs leading to Declines in Hormone Levels.
–The later is an example of
the feedback between cell-level and organ-level functioning showing how damage on one level can cause
damage on the other level
as well.
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