•expression of
NF-kB appears to be one of the body’s regulatory means for handling situations of stress, cancer, damage and
disease. In eukaryotic cells
NF-kB is an important regulator of genes that control cell proliferation and cell survival.
•NF-kB
regulates anti-apoptotic genes that protect healthy cells from cell death and activates the expression of genes that keep
cells proliferating.
•On the other
hand, activated NF-kB binding to genes has long been known to play a central role in promoting runaway inflammation
and inflammation’s negative
consequences.
•Recent
studies indicate that NF-kB signaling
appears is a major regulator of gene expression affecting hundreds of genes related
to the aging progress.
NF-kB cell signaling has been shown to be a meta-factor for determining aging of a number of key cell types
•Inhibition of
NF-kB signaling is being
researched as a cancer therapy and is thought also to be a possible approach to life
extension