–They are two sides of the same coin, representing differing viewpoints of
molecular biology
and cell biology. For example: (cont.)
•Several proteins seem to play key roles in stem cell differentiation, survivin, an
apoptosis inhibitor that is a target of cancer therapies, being a key one. FoxO family members play a critical role in these physiologic
processes in the HSC
compartment and thereby regulate maintenance and integrity of HSCs.
•Effective mTORC1
negative regulation is essential for
keeping the critical balance
between stem cell self-renewal and differentiation: Too little self-renewal or too much differentiation of hematopoietic
stem cells may jeopardize
the ability to sustain hematopoiesis throughout life, whereas excessive self-renewal and/or aberrant differentiation
may result in leukemogenesis.
•TAp63 serves to
maintain adult skin stem cells by regulating cellular senescence and genomic stability, thereby preventing
premature tissue aging
•